Dr. Scialli brings his expertise in the interpretation of experimental animal and epidemiology literature to your regulatory and litigation problems. He has provided consultation on the meaning and significance of data packages in developmental and reproductive toxicology (DART) particularly with respect to regulatory implications. He has functioned with teams preparing for regulatory submissions and hearings.
Dr. Scialli has provided extensive literature reviews for internal use or for publication. His experience as a journal editor, reviewer, and contributor enable him to compile, format, and place papers for publication where they will reach your intended audience. Dr. Scialli has contacts in contract and university laboratories and has placed and monitored studies in these research organizations.
As an experienced medical educator, Dr. Scialli continues to participate in the teaching programs of two academic medical centers. He remains active in lecturing and in the conduct of seminars in the health care arena.
Tony Scialli is a specialist in reproductive and developmental toxicology and in obstetrics and gynecology. In addition to his consulting services, he is Clinical Professor of Obstetrics and Gynecology at George Washington University School of Medicine and Adjunct Professor of Obstetrics and Gynecology and of Pharmacology and Physiology at Georgetown University Medical Center.
Dr. Scialli directs the Reproductive Toxicology Center, a non-profit foundation in Washington, D.C., which maintains Reprotox®, an online data base on the effects on reproduction of drugs, chemicals, biologicals, and physical agents.
Dr. Scialli received his Doctor of Medicine degree from Albany Medical College and completed a residency in obstetrics and gynecology at George Washington University Hospital. He took a fellowship in Reproductive Toxicology with Sergio Fabro, one of the original thalidomide researchers. Dr. Scialli was Professor of Obstetrics and Gynecology and Residency Program Director at Georgetown University Medical Center for many years.
Dr. Scialli continues to be actively involved in medical education and teaches on a regular basis at academic medical centers in Washington, D.C. He founded and was editor-in-chief of the journal Reproductive Toxicology for 17 years and is a past president of the Teratology Society.
A current version of Dr. Scialli's Curriculum Vitae is provided below:
Project completed on time and within budget.
We received a through and comprehensive report, well written, and before the deadline.
Dr. Scialli has an excellent understanding of the field and the regulatory environment.
Excellent presentation; we learned a lot.
Beyer BK, Chernoff N, Danielsson B, Davis-Bruno K, Harrouk W, Hood RD, Janer G, Liminga UW, Kim J, Rocca M, Rogers J, Scialli AR. ILSI/HESI Maternal Toxicity Workshop Summary: Maternal toxicity and its impact on study design and data interpretation. Birth Defects Res (Part B) 2011;92:36-51.Download
Boffetta P, Scialli AR. TCDD and birth weight of Vietnamese infants. Environ Sci Pollution Res 2016;23:17857–17858.Download
Bridges J, Dekant W, Klaunig JE, Scialli AR. Comments on the safety assessment of decamethylcyclopentasiloxane (D5). Regul Toxicol Pharmacol 2017;89:305–306.Download
Carney EW, Ellis AL, Tyl RW, Foster PMD, Scialli AR, Thompson K, Kim J. Critical evaluation of current developmental toxicity testing strategies: A case of babies and their bathwater. Birth Defects Res (Part B) 2011; 92(5):395-403.Download
Damkier P, Scialli AR, Lusskin SI. Acetaminophen in prgnancy and adverse childhood neurodevelopment. JAMA Pediatrics 2017; doi:10.1001/jamapediatrics.2016.5049Download
Chambers C, Scialli AR. Teratogenesis and environmental exposure. In Creasy RK, Resnik R, Iams JD, Lockwood CJ, Moore TR, Greene MF. Creasy & Resnik’s Maternal-Fetal Medicine 7th ed. Philadelphia: Elsevier Saunders; 2014: 465–472.Download
Daston GP, Beyer BK, Carney EW, Chapin RE, Friedman JM, Piersma AH, Rogers JM, Scialli AR. Exposure-based validation list for developmental toxicity screening assays. Birth Defects Res (Part B) 2014;101:423–428.Download
Daston GP, Chapin RE, Scialli AR, Piersma AH, Carney EW, Rogers JM, Friedman JM. A different approach to validating screening assays for developmental toxicity. Birth Defects Res (Part B) 2010;89:526–530.Download
Dekant W, Bridges J, Scialli AR. A quantitative weight of evidence assessment of confidence in modes-of-action and their human relevance. Regul Toxicol Pharmacol 2017;90:51–71.Download
Dekant W, Scialli AR, Plotzke K, Klaunig JE. Biological relevance of effects following chronic administration of octamethylcyclotetrasiloxane (D4) in Fischer 344 rats, Toxicol Lett 2017;279S:42–53.Download
DeSesso JM, Scialli AR. Bone development in laboratory mammals used in developmental toxicity studies. Birth Defects Res 2018; https://doi.org/10.1002/bdr2.1350Download
DeSesso J, Harris S, Scialli A, Williams A. Systematic assessment of quaternary ammonium compounds (QUATS) for the potential to elicit developmental . and reproductive effects. Birth Defects Res 2021;113:1484–1511 DOI: 10.1002/bdr2.1963Download
DeSesso JM, Scialli AR, White TEK, Breckenridge CB. Multigeneration reproduction and male developmental toxicity studies on atrazine in rats. Birth Defects Res (Part B) 2014; DOI: 10.1002/bdrb.21106Download
Fugh-Berman AJ, Scialli AR, Bell AM. Why lunch matters: Assessing physicians’ perceptions about industry relationships. J Cont Ed Health Prof 2010;30(3):197–204.Download
Garey JD, Lusskin SI, Scialli AR. Teratogen update: Amphetamines. Birth Defects Res 2020;112:1161–1182. doi: 10.1002/bdr2.1774Download
Goodman M, Mandel JS, DeSesso JM, Scialli AR. Atrazine and pregnancy outcomes: A systematic review of epidemiologic evidence. Birth Defects Res (Part B) 2014; DOI: 10.1002/bdrb.21101Download
Huo S, Scialli AR, McGarvey S, Hill E, Tügertimur B, Hogenmiller A, Hirsch AI, Fugh-Berman A. Treatment of men for “low testosterone”: A systematic review. PLOS ONE 2016; DOI:10.1371/journal.pone.0162480.Download
Hyoun SC, Običan SG, Scialli AR. Teratogen update: Methotrexate. Birth Defects Res (Part A) 2012; 94(4):187-207.Download
Jean PA, Plotzke KP, Scialli AR. Chronic toxicity and oncogenicity of decamethylcyclopentasiloxane in the Fischer 344 rat. Regul Toxicol Pharmacol 2016; 74:S57–S56.Download
Kim J, Scialli AR. Thalidomide: The tragedy of birth defects and the effective treatment of disease Toxicological Sciences 2011; 122(1):1–6. doi: 10.1093/toxsci/kfr088Download
Klaunig JE, Dekant W, Plotzke K, Scialli AR. Biological relevance of decamethylcyclopentasiloxane (D5) induced rat uterine endometrial adenocarcinoma tumorigenesis: Mode of action and relevance to humans. Regul Toxicol Pharmacol 2016;74:S44–S56.Download
Laufersweiler MC, Gadagbui B, Baskerville-Abraham IM, Maier A, Willis A, Scialli AR, Carr GJ, Felter SP, Blackburn K, Daston G. Correlation of chemical structure with reproductive and developmental toxicity as it relates to the use of the threshold of toxicological concern. Regul Toxicol Pharmacol; 2012; 62:160–182.Download
Običan SG, Finnell RH, Mills JL, Shaw GM, Scialli AR. Folic acid in early pregnancy. A public health success story. FASEB J 2010; 24:4167–4174.Download
Običan SG, Jahnke GD, Soldin OP, Scialli AR. Teratology Society Public Affairs Committee position paper: Iodine deficiency in pregnancy. Birth Defects Res (Part A) 2012; 94(9):677–682.Download
Običan SG, Scialli AR. Teratogenic exposures. Am J Med Genet (Part C) 2011;157(3):150–169.Download
Scialli AR. Developmental and reproductive toxicity evaluation under the European Union REACH regulations. In Hood RD, ed., Developmental and Reproductive Toxicology, Third Ed. New York: Informa Healthcare; 2012:730–735.Download
Scialli AR. Serotonin reuptake inhibitors and heart defects. Reprod Toxicol 2016;63:140–141.Download
Scialli AR. Teratogen? Birth Defects Res 2020;112)15):1103–1104. DOI: 10.1002/bdr2.1746Download
Scialli AR. The National Birth Defects Prevention Study: How to communicate data. Semin Fetal Neonat Med 2014;19:170–176.Download
Scialli AR, Ang R, Breitmeyer J, Royal MA. A review of the literature on the effects of acetaminophen on pregnancy outcome. Reprod Toxicol 2010; 495–507.Download
Scialli AR, Ang R, Breitmeyer J, Royal MA. Childhood asthma and use during pregnancy of acetaminophen. A critical review. Reprod Toxicol 2010; 508–519.Download
Scialli AR, Bonde JP, Brüske-Hohlfeld I, Culver D, Li Y, Sullivan FM. An overview of male reproductive studies of boron with an emphasis on studies of highly exposed Chinese workers. Reprod Toxicol 2010;29:10–24.Download
Scialli AR, Clark RV, Chapin R. The predictivity of non-clinical male reproductive findings for human effects. Birth Defects Res 2017; doi: 10.1002/bdr2.1102Download
Scialli AR, Bailey G, Beyer BK, Bøgh IB, Breslin WJ, Chen CL, DeLise AM, Hui JY, Moffat GJ, Stewart J, Thompson KE. Potential seminal transport of pharmaceuticals to the conceptus. Reprod Toxicol 2015;58:213–221.Download
Scialli AR, Daston G, Chen C, Coder PS, Euling SY, Foreman J, Hoberman AM, Hui J, Knudsen T, Makris SL, Morford L, Piersma AH, Stanislaus D, Thompson KE. Rethinking developmental toxicity testing: Evolution or revolution. Birth Defects Res 2018; DOI: 10.1002/bdr2.1212.Download
Scialli AR, DeSesso JM, Breckenridge CB. Developmental toxicity studies with atrazine and its major metabolites in rats and rabbits. Birth Defects Res (Part B) 2014; DOI: 10.1002/bdrb.21099Download
Scialli AR, Guikema AJ. REACH and reproductive and developmental toxicology: Still questions. Syst Biol Reprod Med 2012;58(1):63–69.Download
Scialli AR, Saavedra K, Fugh-Berman A. The benefits and risks of adherence to medical therapy. JoSPI (Journal of Scientific Practice and Integrity). 2021; https://doi.org/10.35122/001c.21386Download
Scialli AR, Watkins DK, Ginevan ME. Agent Orange exposure and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in human milk. Birth Defects Res (Part B). 2015; 104:129–139.Download
Robinson C, Van Boxmeet J, Tilson H, Scialli A, Vanchere JA, Ides E, Sawlwin D, Molrine D, Hohenboken M, Edelman J, Albano J. Outcomes in pregnant persons immunized with a cell-based quadrivalent inactivated influenza vaccine: A propsective observational cohort study. Vaccines 2022;10:1600. https://doi.org/10.3390/vaccines10101600Download
Robinson C, Oberye J, van Boxmeer J, Albano J, Tilson H, Scialli A, Vanchiere JA, Ides E, Sawlwin D, Hohenboken M, Edelman J. A prospective cohort study on pregnancy outcomes of persons immunized with a seasonal quadrivalent inactivated influenza vaccine during pregnancy. Vaccines 2022;10:1577. https://doi.org/10.3390/vaccines10101577.Download
Wyszynski SD, Bhattacharya M, Martinez-Perez O, Scialli AR, Tassinari M, Bar-Zeev N, Renz C, Hernández-Díaz S. The COVID-19 Vaccines International Pregnancy Exposure Registry (C-VIPER): Protocol and methodological considerations. Drug Safety 2023; https://doi.org/10.21007/s40264-022-01271-3.Download
Scialli Consulting is conveniently located in Washington, D.C., a short walk from the Cleveland Park metro.
2737 Devonshire Pl NW, #120
Washington, D.C. 20008
Office: (202) 249 - 0111
Email Dr. Scialli directly at email@example.com.
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